TAPI-2
货号：
14695-1mg 基本售价：
2744.0 元 规格：
1 mg
产品信息
概述| 货号 | 14695-1mg |
| 描述 | The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit, with an IC50 value of 10 µM.1 TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively.2 In T4-2 breast cancer cells, 20 µM TAPI-2 prevented mobilization of the growth factors TGF-α and amphiregulin leading to reversion of the malignant cellular phenotype.3 |
| 别名 | TNF Protease Inhibitor 2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arribas, J.,Coodly, L.,Vollmer, P., et al. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. The Journal of Biological Chemisty 271(19), 11376-11386 (1996).
2.Moss, M.L. and Rasmussen, F.H. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Analytical Biochemistry 366(2), 144-148 (2007).
3.Kenny, P.A. and Bissell, M.J. Targeting TACE-dependent EGFR ligand shedding in breast cancer. Journal of Clinical Investigation 117(2), 337-345 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 415.5 |
| 分子式 | C19H37N5O5 |
| CAS号 | 187034-31-7 |
| 稳定性 | ≥ 2 years |
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