| 货号 | 8132S |
| 供应商 | CST |
| 背景 | 17-AAG is a semi-synthetic derivative of geldanamycin, demonstrating greater stability than its parent compound (1). It binds specifically to heat shock protein HSP90 in a manner similar to geldanamycin, but with weaker binding (1). Through specific binding with HSP90, 17-AAG has been shown to decrease levels of many proteins including androgen receptor (AR), HER2, and Akt, while increasing levels of HSP90 in prostate cancer cell lines (2). 17-AAG binds to a conserved pocket in the HSP90 family of chaperone proteins and this occupation causes the degradation of several signaling proteins (2). |
| 存放说明 | -20C |
| 参考文献 | 1 . Schulte, T.W. and Neckers, L.M. (1998) Cancer Chemother Pharmacol 42, 273-9. 2 . Solit, D.B. et al. (2002) Clin Cancer Res 8, 986-93. |
Chemical structure of 17-AAG (17-Demethoxy-17-allyaminogeldanmycin)17-AAG的化学结构（17-脱甲氧基-17-烯丙胺基格尔德霉素）。 | |
Western blot analysis of extracts from LNCaP cells, untreated (-) or treated with 17-AAG (1 μM, 24 hr), using Akt (pan) (11E7) Rabbit mAb #4685 (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower).Western blot分析LNCaP细胞提取物，未处理(-)或用17-AAG (1 μM, 24小时，+)处理，使用的抗体是：Akt (pan) (11E7) Rabbit mAb #4685（上图）、β-Actin (13E5) Rabbit mAb #4970（下图）。 |
