| 货号 | 14411-10mg |
| 描述 | (S)-3,5-DHPG, known more commonly as DHPG, is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.1 The (S)-enantiomer is about ten times more potent than the (R)-enantiomer.2 (S)-3,5-DHPG is commonly used to evaluate the roles of group I mGluRs in neuronal signaling.3,4 |
| 别名 | (S)-3,5-Dihydroxyphenylglycine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mutel, V.,Ellis, G.J.,Adam, G., et al. Characterization of [3H]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. Journal of Neurochemistry 75(6), 2590-2601 (2000). 2.Baker, S.R.,Goldsworthy, J.,Harden, R.C., et al. Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist. Bioorganic & Medicinal Chemistry Letters 5(3), 223-228 (1995). 3.Clements, M.A.,Swapna, I. and Morikawa, H. Inositol 1,4,5-triphosphate drives glutamatergic and cholinergic inhibition selectively in spiny projection neurons in the striatum. Journal of Neuroscience 33(6), 2697-2708 (2013). 4.Grolla, A.A.,Sim, J.A.,Lim, D., et al. Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions. Cell Death Dis. (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 183.2 |
| 分子式 | C8H9NO4 |
| CAS号 | 162870-29-3 |
| 稳定性 | ≥ 2 years |
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