Ganglioside GM3 (sodium salt)
货号：
15587-1mg 基本售价：
2685.0 元 规格：
1 mg
产品信息
概述| 货号 | 15587-1mg |
| 描述 | Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events. Gangliosides are often implicated in tumorigenesis since they can modulate cell surface events including proliferation, migration, and adhesion. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. At 20 μM, it can suppress angiogenesis and reduce endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.1,2 Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.3 |
| 别名 | Hematoside;Sialosyllactosylceramide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mukherjee, P.,Faber, A.C.,Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. Journal of Lipid Research 49(5), 929-938 (2008).
2.Seyfried, T.N. and Mukherjee, P. Ganglioside GM3 is antiangiogenic in malignant brain cancer. J.Oncol. 2010, 961243 (2010).
3.Kabayama, K.,Sato, T.,Saito, K., et al. Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proceedings of the National Academy of Sciences of the United States of America 104(34), 13678-13683 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1203.5 |
| 分子式 | C59H107N2O21 • Na |
| CAS号 | 54827-14-4 |
| 稳定性 | ≥ 2 years |
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