| 货号 | 4808/10 |
| 别名 | 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl |
| 供应商 | Tocris |
| 生物活性 | Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251). |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 427.97 |
| 分子式 | C24H29N3O2 |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Travelliet al (2011) Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells. J.Pharmacol.Exp.Ther. 338 829. PMID: 21685314. Galliet al (2008) Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem 3 771. PMID: 18247435. Hasmannet al (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63 7436. PMID: 14612543. |