| 货号 | 18796-25mg |
| 描述 | MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2.1,2 Like the related compound MitoTEMPO (Item No. 16621), MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.2,3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology & Medicine 51(7), 1289-1301 (2011). 2.Choi, H.C.,Song, P.,Xie, Z., et al. Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J. Biol. Chem. 283(29), 20186-20197 (2008). 3.Cunniff, B.,Benson, K.,Stumpff, J., et al. Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells. J. Cell. Physiol. 228(4), 835-845 (2013). 4.Dickey, J.S.,Gonzalez, Y.,Aryal, B., et al. Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. PLoS One 8(8), (2013). 5.Han, Y.,Wang, Q.,Song, P., et al. Redox regulation of the AMP-activated protein kinase. PLoS One 5(11), e15420 (2010). 6.Khan, S.A.,Nanduri, H.,Yuan, G., et al. NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: Relevance to blood pressure changes in rats. Antioxid. Redox Signal. 14(4), 533-542 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 583.6 |
| 分子式 | C32H42NO2P • Br |
| CAS号 | 1101113-39-6 |
| 稳定性 | ≥ 2 years |
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