| 货号 | 21581-5mg |
| 描述 | HO-3867 is an analog of curcumin (Item No. 81025) that selectively suppresses STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.1,2 It has been shown to induce apoptosis in BRCA-mutated ovarian cancer cells with minimal toxicity to normal cells.2,3 HO-3867 is reported to demonstrate synergistic inhibition of chemotherapy-resistant ovarian xenograft tumors when combined with cisplatin (Item No. 13119).1,2 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Selvendiran, K.,Ahmed, S.,Dayton, A., et al. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer Biol. Ther. 12(9), 837-845 (2011). 2.Rath, K.S.,Naidu, S.K.,Lata, P., et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 74(8), 2316-2327 (2014). 3.Tierney, B.J.,McCann, G.A.,Cohn, D.E., et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer. Biol. Ther. 13(9), 766-775 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.6 |
| 分子式 | C28H30F2N2O2 |
| CAS号 | 1172133-28-6 |
| 稳定性 | ≥ 2 years |
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