BQ-788 (sodium salt)
货号：
17403-1mg 基本售价：
2646.0 元 规格：
1 mg
产品信息
概述| 货号 | 17403-1mg |
| 描述 | The endothelin (ET) family of proteins mediate a variety of responses, with ET-1 being a potent and long-lasting constrictor of human cardiovascular vessels.1 These proteins activate the G protein-coupled receptors ETA and ETB, with ETB being non-specific for ET protein form.1 BQ-788 is a potent, selective antagonist of ETB(IC50 = 1.2 nM for blocking ET-1 binding to human Girardi heart cells).2 It weakly inhibits the binding of ET-1 to ETA receptors on human neuroblastoma SK-N-MC cells (IC50 = 1300 nM).2 BQ-788 competitively antagonizes the vasoconstriction induced by an ETB-selective agonist on isolated rabbit pulmonary arteries, blocks ET-1 induced bronchoconstriction in guinea pigs, and abolishes an ET-1 mediated depressor response in rats.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davenport, A.P. International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacological Reviews 54(2), 219-226 (2002).
2.Ishikawa, K.,Ihara, M.,Noguchi, K., et al. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proceedings of the National Academy of Sciences of the United States of America 91(11), 4892-4896 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 664.8 |
| 分子式 | C34H51N5O7 • Na |
| CAS号 | 156161-89-6 |
| 稳定性 | ≥ 2 years |
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