| 货号 | 1310/5 |
| 别名 | 6,12,19,20,25,26-Hexahydro-5,27:13, |
| 供应商 | Tocris |
| 生物活性 | Highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 654.44 |
| 分子式 | C34H30Br2N4 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 199934-16-2 |
| 参考文献 | Campos Rosaet al (2000) Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. J.Med.Chem. 43 420. PMID: 10669569. Malik-Hallet al (2000) Compounds that block intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels. Br.J.Pharmacol. 129 1431. PMID: 10742299. Strobaeket al (2000) Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells. Br.J.Pharmacol. 129 991. PMID: 10696100. |