| 货号 | 1405/10 |
| 别名 | (1R,6S)-3-Hydroxy-4-methyl-7-oxabic |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 154.12 |
| 分子式 | C7H6O4 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| CAS号 | 121-40-4 |
| 参考文献 | Kawakamiet al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227. PMID: 10051623. Subramanianet al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249. PMID: 7080093. Yamamotoet al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320. PMID: 7190624. |