| 货号 | 2945/10U |
| 供应商 | Tocris |
| 生物活性 | Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4495.01 |
| 分子式 | C192H274N52O |
| 可溶性/溶解性 | Soluble in water |
| 序列号 | GVDKAGCRYMFGGCSVNDDCCPRLGCHSLF (Modifications: Disulfide bridge between 7 - 21, 14 - 26, 20 - 33) |
| 参考文献 | Matthewset al (2007) The CaV2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur.J.Neurosci. 25 3561. PMID: 17610575. Bourinetet al (2001) Interaction of SNX482 with domains III and IV inhibits activation gating of α1E(CaV2.3) calcium channels. Biophys.J. 81 79. PMID: 11423396. Newcombet al (1998) Selective peptide antagonist of the class E calcium channel from the venom of the Tarantula Hysterocrates gigas. Biochemistry 37 15353. PMID: 9799496. |