| 货号 | 1965/50 |
| 别名 | (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexa |
| 供应商 | Tocris |
| 生物活性 | HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 418.57 |
| 分子式 | C25H38O5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 75 mM in ethanol |
| CAS号 | 79902-63-9 |
| 参考文献 | Kaushalet al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49. PMID: 12699077. Reinosoet al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593. PMID: 12616706. Garrettet al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715. PMID: 11405194. White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111. PMID: 11563401. |