| 货号 | 2614/1 |
| 别名 | (αS)-N-[(1S)-3-Amino-1-[[(phenylmeth |
| 供应商 | Tocris |
| 生物活性 | Selective protease-activated receptor-1 (PAR1) antagonist; displays no activity at PAR2, PAR3, or PAR4 subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >96 % |
| 计算分子量 | 863.65 |
| 分子式 | C41H43Cl2F2< |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| 参考文献 | Zaniaet al (2006) Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J.Pharmacol.Exp.Ther. 318 246. PMID: 16595737. Maryanoffet al (2003) Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr.Med.Chem.Cardiovasc.Hematol.Agents 1 13. PMID: 15317288. Andrade-Gordonet al (1999) Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc.Natl.Acad.Sci.USA 96 12257. PMID: 10535908. |