| 货号 | 2992/1 |
| 别名 | [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,1 |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α,β,γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 570.64 |
| 分子式 | C35H30N4O4 |
| 可溶性/溶解性 | Soluble to 15 mM in DMSO |
| CAS号 | 120685-11-2 |
| 参考文献 | Nakazono-Kusabaet al (2004) PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur.J.Pharmacol. 497 155. PMID: 15306200. Tenzeret al (2001) The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61 8203. PMID: 11719451. Fabbroet al (2000) PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15 17. PMID: 10888033. |