| 货号 | 2338/10 |
| 别名 | 3-[[[3-[(1E)-2-(7-Chloro-2-quinolin |
| 供应商 | Tocris |
| 生物活性 | Potent CysLT1(LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 515.09 |
| 分子式 | C26H27ClN2O3S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 115104-28-4 |
| 参考文献 | Dupreet al (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102. PMID: 14718577. Blain and Sirois (2000) Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571. Prost.Leuko.Essent.Fatty Acids 62361. Vellengaet al (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 127 441. PMID: 10385244. |