| 货号 | 1331/1 |
| 别名 | 5-[[(2,5-Dihydroxyphenyl)methyl][(2 |
| 供应商 | Tocris |
| 生物活性 | Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 381.38 |
| 分子式 | C21H19NO6 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 25 mM in DMSO |
| CAS号 | 125697-92-9 |
| 参考文献 | Hsuet al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105. PMID: 1939153. O'Dellet al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558. PMID: 1656271. Onodaet al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252. PMID: 2614420. |