| 货号 | 3973/100U |
| 别名 | 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo |
| 供应商 | Tocris |
| 生物活性 | Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 421.55 |
| 分子式 | C22H31NO5S |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Mortonet al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376. PMID: 10854330. Yarmolaet al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120. PMID: 10859320. Blasbergeret al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 19891171. |