| 货号 | 1629/100U |
| 别名 | (15R)-17-demethoxy-15-methoxy-11-O- |
| 供应商 | Tocris |
| 生物活性 | Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 574.67 |
| 分子式 | C30H42N2O9 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244. PMID: 16218955. McCollumet al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987. PMID: 15051479. Fukazawaet al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155. PMID: 8131836. |