| 货号 | 1768/1 |
| 别名 | (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5- |
| 供应商 | Tocris |
| 生物活性 | Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 458.55 |
| 分子式 | C26H34O7 |
| 可溶性/溶解性 | Soluble to 3 mM in ethanol |
| CAS号 | 23110-15-8 |
| 参考文献 | Rodriguez-Nietoet al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509. Lowtheret al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455. Ingberet al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033. Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977. |