货号 | 0439/100 |
别名 | 8-Cyclopentyl-1,3-dipropylxanthine |
供应商 | Tocris |
生物活性 | Potent and selective A1 adenosine receptor antagonist, both in vitroandin vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >99 % |
计算分子量 | 304.39 |
分子式 | C16H24N4O2 |
可溶性/溶解性 | Soluble to 5 mM in DMSO and to 10 mM in ethanol |
CAS号 | 102146-07-6 |
参考文献 | Canalset al (2008) Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves. J.Cereb.Blood Flow Metab. 28 1835. PMID: 18612316. Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382. PMID: 11111832. Kuanet al (1992) An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo. J.Pharmacol.Exp.Ther. 263 657. PMID: 1432696. Von der Leyen (1989) Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch.Pharmacol. 340 204. PMID: 2554151. |