| 货号 | 3493/1 |
| 别名 | Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]) |
| 供应商 | Tocris |
| 生物活性 | Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 779.98 |
| 分子式 | C44H57N7O6 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 20% ethanol / water |
| CAS号 | 84211-54-1 |
| 序列号 | FWKT (Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr) |
| 参考文献 | Guoet al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61. PMID: 18640104. Stirnweiset al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503. PMID: 12182954. Frieset al (1982) Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat. Peptides 3 811. PMID: 6129618. |