| 货号 | 1188/500U |
| 供应商 | Tocris |
| 生物活性 | Selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 611 |
| 分子式 | C31H42N6O7 |
| 可溶性/溶解性 | Soluble to 0.40 mg/ml in water |
| 序列号 | WDPVL (Modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized) |
| 参考文献 | Agapitov and Haynes (2002) Role of endothelin in cardiovascular disease. J.Renin Angiotensin Aldosterone Syst. 3 1. PMID: 11984741. Makataniet al (2000) Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics. Eur.J.Pharmacol. 406 139. PMID: 11011045. Ekelundet al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887. PMID: 7921617. Sakamotoet al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547. PMID: 8473300. |