| 货号 | 4960/1 |
| 别名 | 6-[(3,5-Dimethyl-1H-pyrazol-4-yl)me |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and <10 nM respectively). Exhibits no activity at MCT4. Blocks proliferation of Raji lymphoma cells in vitro. Inhibits glycolysis and glutathione synthesis in cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 461.53 |
| 分子式 | C21H27N5O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Dohertyet al (2014) Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res. 74 908. PMID: 24285728. Ovenset al (2010) The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem.J. 431 217. PMID: 20695846. Ovenset al (2010) AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem.J. 425 523. PMID: 19929853. |