| 货号 | 1954/1 |
| 别名 | [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11) |
| 供应商 | Tocris |
| 生物活性 | Substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 951.2 |
| 分子式 | C49H66N12O6S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 115150-59-9 |
| 序列号 | RWFWLM (Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide) |
| 参考文献 | MacKinnonet al (2000) [Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br.J.Cancer 83 941. PMID: 10970698. Langdonet al (1992) Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 52 4554. PMID: 1379515. Woll and Rozengurt (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 50 3968. PMID: 1693879. |