| 货号 | 4853/100U |
| 别名 | 8-(4-Chlorophenylthio)-2'-O-methylad |
| 供应商 | Tocris |
| 生物活性 | Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645). This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage. |
| 运输条件 | Blue Ice |
| 存放说明 | -80℃ |
| 纯度 | >97 % |
| 计算分子量 | 557.9 |
| 分子式 | C20H21ClN5O8 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Almahariqet al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122. PMID: 23066090. Tsalkovaet al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.U.S.A. 109 18613. PMID: 23091014. Chepurnyet al (2009) Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J.Biol.Chem. 284 10728. PMID: 19244230. Vliemet al (2008) 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem. 9 2052. PMID: 18633951. |