| 货号 | 1645/1 |
| 别名 | 8-(4-Chlorophenylthio)-2'-O-methylad |
| 供应商 | Tocris |
| 生物活性 | Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cellsin vitro. Cell permeable analog (Cat. No. 4853) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 507.82 |
| 分子式 | C17H16ClN5O6PS.Na |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Kanget al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279. PMID: 12496249. Enserinket al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901. PMID: 12402047. Kawasakiet al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275. PMID: 9856955. |