| 货号 | 1852/1 |
| 别名 | (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hy |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 292.34 |
| 分子式 | C18H16N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 856925-71-8 |
| 参考文献 | Limouzeet al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337. PMID: 15548862. Straightet al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743. PMID: 12637748. Straightet al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515. |