| 货号 | 14931-10mg |
| 描述 | CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).1,2 It binds directly with the pathway activator Smoothened (Ki = 44 nM).3 CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.1,4 |
| 别名 | G-856; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Williams, J.A.,Guicherit, O.M.,Zaharian, B.I., et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions. Proceedings of the National Academy of Sciences of the United States of America 100(8), 4616-4621 (2003). 2.Manetti, F.,Faure, H.,Roudaut, H., et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Molecular Pharmacology 78(4), 658-665 (2010). 3.Frank-Kamenetsky, M.,Zhang, X.M.,Bottega, S., et al. Small-molecule modulators of Hedgehog signaling: Identification and characterization of smoothened agonists and antagonists. J.Biol. 1(2), (2002). 4.Tang, T.,Tang, J.Y.,Li, D., et al. Targeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clinical Cancer Research 17(10), 3378-3387 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 550.7 |
| 分子式 | C31H42N4O5 |
| CAS号 | 334998-36-6 |
| 稳定性 | ≥ 2 years |
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