Amorfrutin A
货号：
21106-500ug 基本售价：
2590.0 元 规格：
500 ug
产品信息
概述| 货号 | 21106-500ug |
| 描述 | Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosaandG. foetida that exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 µM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 µM.1 In high-fat diet-induced obese (DIO) mice, amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations.1 Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 µM.2,3 |
| 别名 | Amorfrutin 1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Weidner, C.,de Groot, J.C.,Prasad, A., et al. Amorfrutins are potent antidiabetic dietary natural products. Proc. Natl. Acad. Sci. USA 109(19), 7257-7262 (2012).
2.Shi, H.,Ma, J.,Mi, C., et al. Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products. Int. Immunopharmacol. 21(1), 56-62 (2014).
3.Fuhr, L.,Rousseau, M.,Plauth, A., et al. Amorfrutins are natural PPARg agonists with potent anti-inflammatory properties. J. Nat. Prod. 78(5), 1160-1164 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 340.4 |
| 分子式 | C21H24O4 |
| CAS号 | 80489-90-3 |
| 稳定性 | ≥ 2 years |
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