Cholera Toxin (azide free)
货号：
19654-1mg 基本售价：
2590.0 元 规格：
1 mg
产品信息
概述| 货号 | 19654-1mg |
| 描述 | Cholera toxin is produced by V. cholerae and is a multimeric enterotoxin that consists of a single A subunitsurrounded by five B subunits.1 Following binding to the membrane of enteric cells, the toxin is endocytosed and travels to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase, locking it in an ‘on’ position.2 The increased intracellular concentration of cAMP causes hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and severe diarrhea characteristic of the disease cholera.1 |
| 别名 | Choleragen;CT; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cho, J.A.,Chinnapen, D.J.F.,Amar, E., et al. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front.Cell.Infect.Microbiol. 11, 2(51) (2012).
2.van Heyningen, S., and King, C.A. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes. Biochemistry Journal 146(1), 269-271 (1975).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 2-8 |
| 纯度 | ≥95% (estimated by SDS-PAGE) |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
