Estradiol 3-(β-D-Glucuronide) (sodium salt)
货号：
16155-5mg 基本售价：
2576.0 元 规格：
5 mg
产品信息
概述| 货号 | 16155-5mg |
| 描述 | Estradiol 3-(β-D-glucuronide) (E23G) is a non-cholestatic regioisomer of the estrogen metabolite, estradiol 17-(β-D-glucuronide) (E217G; Item No. 16156).1,2 It acts as a substrate for multidrug resistance protein 2 (MRP2; Km = 122 µM), competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM).2,3E23G has been reported to inhibit E217G transport through rat organic anion-transporting polypeptide 1 with a Ki value of 9.7 µM, but is a low-affinity inhibitor of both MRP4 and MRP7 (IC50s = ~ 100 µM).2 |
| 别名 | E23G;β-Estradiol 3-(β-D-Glucuronide);17β-Estradiol 3-(β-D-Glucuronide);17β-Oestradiol 3-(β-D-Glucuronide); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Loe, D.W.,Almquist, K.C.,Cole, S.P., et al. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. The Journal of Biological Chemisty 271(16), 9683-9689 (1996).
2.Gerk, P.M.,Li, W. and Vore, M. Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide. Drug Metabolism and Disposition 32(10), 1139-1145 (2004).
3.Gerk, P.M.,Li, W.,Megaraj, W., et al. Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. Journal of Pharmacology and Experimental Therapeutics 320(2), 893-899 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 470.5 |
| 分子式 | C24H31O8 • Na |
| CAS号 | 14982-12-8 |
| 稳定性 | ≥ 2 years |
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