SB 265610
货号：
17879-10mg 基本售价：
2548.0 元 规格：
10 mg
产品信息
概述| 货号 | 17879-10mg |
| 描述 | CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and many other CXC chemokines involved in the trafficking and activation of inflammatory cells. It is involved in various inflammatory diseases, including chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis. SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site.1,2 It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.de Kruijf, P.,van Heteren, J.,Lim, H.D., et al. Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor. Journal of Pharmacology and Experimental Therapeutics 329(2), 783-790 (2009).
2.Bradley, M.E.,Bond, M.E.,Manini, J., et al. SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Brit.J.Pharmacol. 158, 328-338 (2009).
3.Auten, R.L.,Richardson, R.M.,White, J.R., et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. Journal of Pharmacology and Experimental Therapeutics 299, 90-95 (2001).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.2 |
| 分子式 | C14H9BrN6O |
| CAS号 | 211096-49-0 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
