| 货号 | 5305/10 |
| 别名 | (4R,4aS)-18-Ethenyl-4,4a-dihydro-3, |
| 供应商 | Tocris |
| 生物活性 | YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 718.79 |
| 分子式 | C41H42N4O8 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Brodowskaet al (2014) The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67. PMID: 24837142. Songet al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170. PMID: 24906622. Liu-Chittendenet al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300. PMID: 22677547. |