货号 | 1742/10 |
别名 | (2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl |
供应商 | Tocris |
生物活性 | Potent, selective 5-HT2 receptor antagonist; displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM). IC50 values are 2.2, 310, 2400, 3700, > 5000 and > 5000 nM for 5-HT2,α1-adrenergic, D2 dopamine, 5-HT1, 5-HT3andβ-adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >99 % |
计算分子量 | 391.94 |
分子式 | C22H29NO3.HCl |
可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
CAS号 | 167144-79-8 |
参考文献 | Ogawaet al (2005) Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. Eur.J.Pharmacol. 521 156. PMID: 16183055. Ogawaet al (2002) Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444. Eur.J.Pharmacol. 457 107. PMID: 12464356. Tanakaet al (2000) [2-(ω-Phenylalkyl)phenoxy]alkylamines III: Synthesis and selective serotonin-2 receptor binding. Chem.Pharm.Bull. 48 1729. PMID: 11086903. |