| 货号 | 18142-1mg |
| 描述 | β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi.1 It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.2,3 The biological activity of this toxin is similar to that of α-amanitin (Item No. 17898) but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Walton, J.D.,Hallen-Adams, H.E., and Luo, H. Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms. Biopolymers 94(5), 659-664. 2.Gu, W.,Powell, W.,Mote, J., Jr., et al. Nascent RNA cleavage by arrested RNA polymerase II does not require upstream translocation of the elongation complex on DNA. J.Biol.Chem 268(34), 25604-25616 (1993). 3.Tipper, D.J. Inhibition of yeast ribonucleic acid polymerases by thiolutin. Journal of Bacteriology 116(1), 245-256 (1973). 4.Anderl, J.,Echner, H., and Faulstich, H. Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology. Beilstein J.Org.Chem. 8, 2072-2084 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 920 |
| 分子式 | C39H53N9O15S |
| CAS号 | 21150-22-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |