TCN 237 dihydrochloride (10 MG)
货号：
4072/10 基本售价：
2458.8 元 规格：
10 mg
产品信息
概述| 货号 | 4072/10 |
| 别名 | 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Highly potent NR2B-selective NMDA receptor antagonist (Ki = 0.8 nM); blocks NR2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Selective for NR2B subunit over α1-adrenergic receptors and hERG channels (IC50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 412.33 |
| 分子式 | C20H22FN3O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | McCauleyet al (2004) NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J.Med.Chem. 47 2089. PMID: 15056006. |
