| 货号 | 3715/1 |
| 别名 | (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro- |
| 供应商 | Tocris |
| 生物活性 | Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 307.26 |
| 分子式 | C14H13NO7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Ingrassiaet al (2009) Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 52 1100. PMID: 19199649. Lefrancet al (2009) Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 8 1739. PMID: 19531573. Dumontet al (2007) The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 9 766. PMID: 17898872. |