| 货号 | 4738/1 |
| 别名 | (9S)-9-[(Dimethylamino)methyl]-6,7, |
| 供应商 | Tocris |
| 生物活性 | Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 505.01 |
| 分子式 | C28H28N4O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Faulet al (2003) Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ. Bioorg.Med.Chem.Lett. 13 1857. PMID: 12749884. Samokhinet al (1999) Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. Eur.J.Pharmacol. 386 297. PMID: 10618482. Jirouseket al (1996) (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase Cβ. J.Med.Chem. 39 2664. PMID: 8709095. |