| 货号 | 5290/1 |
| 供应商 | Tocris |
| 生物活性 | EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1465.75 |
| 分子式 | C74H108N14O1 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | KYLPYWPVLSSL |
| 参考文献 | Vargaset al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One. 9 e92309. PMID: 24658113. Lambertoet al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47. PMID: 22489865. |