| 货号 | 2287/1 |
| 别名 | 6,7,12,13-Tetrahydro-5H-indolo[2,3- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 311.34 |
| 分子式 | C20H13N3O |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 85753-43-1 |
| 参考文献 | McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478. PMID: 12672248. Zimmermannet al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49. PMID: 11080540. Fabreet al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193. PMID: 8081852. |