| 货号 | 4997/10 |
| 别名 | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-ben |
| 供应商 | Tocris |
| 生物活性 | DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 235.3 |
| 分子式 | C12H13NO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Pozoet al (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 123 2475. PMID: 23635774. Ogawaet al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86. PMID: 20981014. |