| 货号 | 3501/1 |
| 供应商 | Tocris |
| 生物活性 | Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 744.42 |
| 分子式 | C34H66ClN11O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | RVKR (Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone) |
| 参考文献 | Tian and Jianhua (2010) Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 6 89. PMID: 20151049. Garciaet al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595. PMID: 16221685. Denaultet al (1995) Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 26 S47. PMID: 8587448. |