| 货号 | 1639/10 |
| 别名 | trans-N,N-bis[2-Chlorophenylmethyl] |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 464.3 |
| 分子式 | C22H28Cl2N2.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 366-93-8 |
| 参考文献 | Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193. PMID: 10712926. Cooperet al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603. PMID: 9616123. Moebiuset al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899. PMID: 9465114. Kramlet al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455. PMID: 4283982. |