| 货号 | 4474/10 |
| 别名 | (3β)-Cholest-5-ene-3,20-diol |
| 供应商 | Tocris |
| 生物活性 | Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 402.65 |
| 分子式 | C27H46O2 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol |
| 参考文献 | Nedelcuet al (2013) Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat.Chem.Biol. 9 557. PMID: 23831757. Nachtergaeleet al (2012) Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat.Chem.Biol. 8 211. PMID: 22231273. Dwyeret al (2007) Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells J.Biol.Chem. 282 8959. PMID: 17200122. |