| 货号 | 4272/1 |
| 供应商 | Tocris |
| 生物活性 | Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1570.79 |
| 分子式 | C74H99N21O16 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | YVMGHFRWDRFG (Modifications: Trp-8 = D-Trp) |
| 参考文献 | Patelet al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835. PMID: 20702773. Gettinget al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850. PMID: 16959942. Griecoet al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998. PMID: 11150170. |