α-Amanitin
货号：
17898-1mg 基本售价：
2450.0 元 规格：
1 mg
产品信息
概述| 货号 | 17898-1mg |
| 描述 | α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.1 At 1, 10, and 50 µg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.2,3 RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hallen, H.E.,Luo, H.,Scott-Craig, J.S., et al. Gene family encoding the major toxins of lethal Amanita mushrooms. Proceedings of the National Academy of Sciences of the United States of America 104(48), 19097-19101 (2007).
2.Gu, W.,Powell, W.,Mote, J., Jr., et al. Nascent RNA cleavage by arrested RNA polymerase II does not require upstream translocation of the elongation complex on DNA. J.Biol.Chem 268(34), 25604-25616 (1993).
3.Tipper, D.J. Inhibition of yeast ribonucleic acid polymerases by thiolutin. Journal of Bacteriology 116(1), 245-256 (1973).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 919 |
| 分子式 | C39H54N10O14S |
| CAS号 | 23109-05-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
