Octyl-α-ketoglutarate
货号：
11970-5mg 基本售价：
2394.0 元 规格：
5 mg
产品信息
概述| 货号 | 11970-5mg |
| 描述 | Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.1 Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.2 When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.2,3 In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.2 |
| 别名 | α-KG octyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gottlieb, E., and Tomlinson, I.P.M. Mitochondrial tumour suppressors: A genetic and biochemical update. Nature Reviews.Cancer 5, 857-866 (2005).
2.MacKenzie, E.D.,Selak, M.A.,Tennant, D.A., et al. Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Molecular and Cellular Biology 27(9), 3282-3289 (2007).
3.Zhao, S.,Lin, Y.,Xu, W., et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324(5924), 261-265 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 258.3 |
| 分子式 | C13H22O5 |
| CAS号 | 876150-14-0 |
| 稳定性 | ≥ 1 year |
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