| 货号 | 1550/10 |
| 别名 | 5-(4-Chlorophenyl)-1-(4-methoxyphen |
| 供应商 | Tocris |
| 生物活性 | Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 352.74 |
| 分子式 | C17H12ClF3N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 188817-13-2 |
| 参考文献 | Daikokuet al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735. PMID: 15867369. Takeuchiet al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475. PMID: 15974942. Smithet al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313. PMID: 9789085. |