| 货号 | 3052/10 |
| 别名 | 5-[[4,5-Dimethoxy-2-(methylethyl)ph |
| 供应商 | Tocris |
| 生物活性 | Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 302.37 |
| 分子式 | C16H22N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Donnelly-Robertset al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409. PMID: 18042830. Fordet al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. PMID: 16465177. Geveret al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452513. |