| 货号 | 5151/1 |
| 供应商 | Tocris |
| 生物活性 | Potent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1579.72 |
| 分子式 | C69H110N16O2 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | TXLIDNNATEEILY (Modifications: Ala-2 = D-Ala) |
| 参考文献 | Meyeret al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529. PMID: 23690594. Hiraiwaet al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 94 4778. PMID: 9114068. |